منابع مشابه
Optimization of Cardiac Metabolism in Heart Failure
The derangement of the cardiac energy substrate metabolism plays a key role in the pathogenesis of heart failure. The utilization of non-carbohydrate substrates, such as fatty acids, is the predominant metabolic pathway in the normal heart, because this provides the highest energy yield per molecule of substrate metabolized. In contrast, glucose becomes an important preferential substrate for m...
متن کاملCardiac metabolism in heart failure: implications beyond ATP production.
The heart has a high rate of ATP production and turnover that is required to maintain its continuous mechanical work. Perturbations in ATP-generating processes may therefore affect contractile function directly. Characterizing cardiac metabolism in heart failure (HF) revealed several metabolic alterations called metabolic remodeling, ranging from changes in substrate use to mitochondrial dysfun...
متن کاملAltered Cardiac High-Energy Phosphate Metabolism in Heart Failure
Background. The purpose of this work was to further define the value of cardiac 3'P magnetic resonance (MR) spectroscopy for patients with coronary artery disease and dilated cardiomyopathy. Methods and Results. Blood-corrected and Tl-corrected 3`P MR spectra of anteroseptal myocardium were obtained at rest using image-selected in vivo spectroscopy localization, a selected volume of 85± 12 cm3,...
متن کاملHuge Intracavitary Cardiac Hyadatid Cyst Presenting with Heart Failure
Although cardiac involvement is an infrequent presentation in human hydatidosis, early diagnosis and prompt surgical intervention of cardiac hydatid cyst are of utmost importance for the prevention of potential complications. We report a young female patient who presented with a huge cardiac hydatid cyst and severe heart failure symptoms undergoing successful surgical cyst removal with late fol...
متن کاملExercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure
Objective(s): Exercise training is a well-known accelerator for the treatment of chronic heart failure (CHF). The current study aimed to investigate the restorative effects of aerobic interval training (AIT) intervention on myocardial energy metabolism in CHF rats. Materials and Methods: Post-myocardial infarction (MI) heart failure animal model was established. The Sprague-Dawley rats were ran...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2013
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.113.300376